Abstract Search

ea0073oc7.5 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hepatic O-GlcNAcylated-p53 as a hub integrating the glucose counterregulatory response and insulin-suppressed gluconeogenesis

González Rellán María Jesús , Fernández Fondevila Marcos , Fernández Paz Uxia , Rodríguez Amaia , Varela Rey Marta , Veyrat-Durebex Christelle , Seoane Samuel , Bernardo Ganeko , Fernando Lopitz Otsoa , Fernandez Ramos David F , Bilbao Jon , Iglesias Cristina , Müller David F , Herzig Stephan , Martinez Chantar Maria Luz , Perez Fernandez Roman , Lopez Miguel , Diéguez Roman , Maria Mato Jose , Millet Oscar , Coppari Roberto , Woodhoo Ashwin , Fruhbeck Gema , Nogueiras Pozo Rubén

Background and aimsGlucose homeostasis is essential for life. The liver is among the key tissues for maintaining an adequate metabolic homeostasis and its alterations are at the root of the pathogenesis of many disease states. A perfect balance between glucose production, mainly at the liver, and glucose consumption in different tissues, is provided by the action of insulin and counterregulatory hormones as glucagon, cortisol or catecholamines. There is ...

0 shares

Endocrine Abstracts

Hepatic O-GlcNAcylated-p53 as a hub integrating the glucose counterregulatory response and insulin-suppressed gluconeogenesis

BiosciAbstracts